Publications

Stephanie M. Wilk, Kihak Lee, Alexa M. Gajda, Mohamed Haloul, Virgilia Macias, Elizabeth L. Wiley, Zhengjia Chen, Xinyi Liu, Xiaowei Wang, Maria Sverdlov, Kent F. Hoskins, Ekrem Emrah Er (2024) Multiplex Imaging Reveals Novel Subcellular, Microenvironmental, and Racial Patterns of MRTFA/B Activation in Invasive Breast Cancers and Metastases. BioRXiv

Er, E.E.*, Tello-Lafoz, M. Huse, M. (2022) Mechanoregulation of Metastasis beyond the Matrix. Cancer Research. 82 (19): 3409–3419 *Corresponding author

Tello-Lafoz, M., Srpan, Sanchez, E.E., K., Hu, J., Remsik, J., Romin, Y., Calo, A., Hoen, D., Bhanot, U., Morris, L., Boire, A., Hsu, K.C., Massague, J., Huse, M.*, and Er, E.E.* (2021) Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer. Immunity.  *Co-corresponding authors. pre-print: bioRxiv, 2020.2004.2021.054304. Ø  Highlighted in “Mechanosurveillance of tumour metastasis”. Nat Rev Immunol 21, 274–275 (2021). https://doi.org/10.1038/s41577-021-00546-7Ø  Highlighted in Mechanosurveillance of tumour metastasis. Nat Rev Cancer 21, 342–343 (2021). https://doi.org/10.1038/s41568-021-00360-2Ø  Research Watch: “Cytotoxic Immune Cells Suppress Metastasis via Mechanical Sensing”. Cancer Discovery. (2021) May https://doi.org/10.1158/2159-8290.CD-RW2021-049Ø  Preview: “Cancer cells relax and resist cytotoxic attack”. Immunity. (2021) May https://doi.org/10.1016/j.immuni.2021.04.017Ø  Highlighted at Faculty Opinions by Ronen Alon and Robert Knobler

Er., E.E., Boire, A. (2020) Molecular Mechanisms in Brain Metastasis. In Manmeet Ahluwalia et al., (Eds), Central Nervous System Metastases. Springer International Publishing. Su, J., Morgani, S.M., David, C.J. Wang, Q., Er, E.E., Huang, Y., Basnet, H., Zou, Y., Shu, W., Soni, R.K., Hendrickson, R.C., Hadjantonakis, A., and Massagué J. (2020) TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1. Nature 577, 566–571.  Ganesh, K., Basnet, H., Kaygusuz, Y., Laughney, A.M., He, L., Sharma, R., O’Rourke, K., Reuter, V., Huang, Y.H., Turkekul, M., Er, E.E., Masilionis, I., Manova-Todorova, K., Weiser, M.B., Saltz, L.B., Aguilar, J.G., Koche, R., Lowe, S., Pe’er, D., Shia, J., Massagué, J. (2020) L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer. Nature Cancer
Gomes, A.P., Ilter, D., Low, V., Rosenzweig, A., Shen, Z.J., Er, E.E., Schild, T., Rivas, M.A., McNally, D.R., Mutvai, A., Han, J., Nagiec, M., Mullarky, E., Ou, Y.H., Shin, S., Massague, J., Melnick, A., Cantley, L.C., Tyler, J., Blenis, J.  (2019) Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Cancer Cell 36(4):402-417
Er, E.E., Valiente, M., Ganesh, K., Zou, Y., Agrawal, S., Hu, J., Griscom, B., Rosenblum, M., Boire, A., Brogi, E.,  Giancotti, F.F., Schachner, M., Malladi, S., Massagué, J. (2018) Pericyte-Like Spreading by Disseminated Cancer Cells Activates YAP and MRTF for Metastatic Colonization. Nature Cell Biology 20, 966-978Ø  Highlighted in “The mechanics of metastatic seeding” Nature Cell Biology 20, 860-862 (2018).Ø  Highligted by MSKCC OnCancer BlogØ  “Breaking Insights, Highlights from Recent Cancer Literature” Cancer Research 78, 5190Ø   Highlighted at Faculty Opinions by Andrew Dudley, Guido Serini and Donatella Valdembri Chen, Q.*, Boire, A.*, Jin, X., Valiente, M., Er, E.E., Lopez-Soto, A., Jacob, L.S., Patwa, R., Shah, H., Ke, X., Cross, J.R., Massagué, J. (2016) Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature 533, 493-498 Er, E.E., Mendoza, M.C., Mackey, A.M., Rameh, L.E., Blenis, J. (2013) AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve. Science Signaling 6, ra45. Mendoza, M.C., Er, E.E., Zhang, W., Ballif, B.A., Elliott, H.L., Danuser, G., and Blenis, J. (2011). ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex. Molecular Cell 41, 661-671. Mendoza, M.C., Er, E.E., and Blenis, J (2011) The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation. Trends in Biochemical Sciences 36, 320-328. Mendoza, M.C., Er, E.E., and Blenis, J (2010) ERK-MAP Kinase Signaling in the Cytoplasm. In Rony Seger (Ed), Methods in Molecular Biology (661, 185-203) Clifton, N.J: Humana Press.